Multiple Endocrine Neoplasia Type 1 Presenting as Hypoglycemia due to Insulinoma
Journal of Korean Medical Science
; : 1003-1006, 2016.
Article
em En
| WPRIM
| ID: wpr-224843
Biblioteca responsável:
WPRO
ABSTRACT
Multiple endocrine neoplasia (MEN) mutation is an autosomal dominant disorder characterized by the occurrence of parathyroid, pancreatic islet, and anterior pituitary tumors. The incidence of insulinoma in MEN is relatively uncommon, and there have been a few cases of MEN manifested with insulinoma as the first symptom in children. We experienced a 9-year-old girl having a familial MEN1 mutation. She complained of dizziness, occasional palpitation, weakness, hunger, sweating, and generalized tonic-clonic seizure that lasted for 5 minutes early in the morning. At first, she was only diagnosed with insulinoma by abdominal magnetic resonance images of a 1.3 × 1.5 cm mass in the pancreas and high insulin levels in blood of the hepatic vein, but after her father was diagnosed with MEN1. We found she had familial MEN1 mutation, and she recovered hyperinsulinemic hypoglycemia after enucleation of the mass. Therefore, the early genetic identification of MEN1 mutation is considerable for children with at least one manifestation.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Neoplasias Pancreáticas
/
Linhagem
/
Convulsões
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Análise Mutacional de DNA
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Imageamento por Ressonância Magnética
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Sequência de Bases
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Proteínas Proto-Oncogênicas
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Neoplasia Endócrina Múltipla Tipo 1
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Polimorfismo de Nucleotídeo Único
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Alelos
Tipo de estudo:
Prognostic_studies
Limite:
Child
/
Female
/
Humans
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2016
Tipo de documento:
Article