Effects of Rebamipide Against Nonsteroidal Anti-inflammatory Drugs (NSAIDs)Induced Gastroduodenal Mucosal Injury / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
; : 73-80, 2001.
Article
em Ko
| WPRIM
| ID: wpr-224874
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES:
To investigate protective effect of rebamipide against nonsteroidal anti-inflammatory drugs (NSAIDs)induced gastroduodenal mucosal injury.METHODS:
Randomized eight patients with rheumatic disease starting NSAIDs underwent pre-treatment gastroduodenoscopy,and degree of mucosal injury and several gastrointestinal (GI)symptoms were graded by Lanza score scale (rating from 0 to 4)and symptom score scale (rating from 0 to 3).Eight weeks after the subjects had received concomitant rebamipide 100mg bid and NSAIDs they underwent post-treatment gastroduodenoscopy and degree of mucosal injury and GI symptoms were graded.Randomized previous NSAIDs-used 20 patients with rheumatic disease were also investigated.Eight weeks after 100mg bid with concomitant NSAIDs,they underwent gastroduodenoscopy and degree of mucosal injury and GI symptoms were graded.RESULTS:
All eight patients who received concomitant rebamipide and NSAIDs had no interval changes between pre and post-treatment mucosal injury scores and had little interval changes between pre and post-treatment symptom scores. In previous NSAIDs-used patients with rheumatic disease,incidence of each gastric ulcer and duodenal ulcer were 16.7%and 11.1%and all mean symptom scores were lower than 1.0.No special adverse effect was developed during the study.CONCLUSION:
Rebamipide seems to have a good protective effect against NSAIDs induced mucosal injury and GI symptoms and probably have rare adverse effect.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Úlcera Gástrica
/
Anti-Inflamatórios não Esteroides
/
Doenças Reumáticas
/
Úlcera Duodenal
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
Ko
Revista:
The Journal of the Korean Rheumatism Association
Ano de publicação:
2001
Tipo de documento:
Article