Comparison of Atypical Antipsychotics Discontinuation Rate in Acute Phase Hospitalized Patients-Retrospective Chart Review Study / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 130-136, 2010.
Article
em Ko
| WPRIM
| ID: wpr-225666
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: The purpose of this study was to compare the discontinuation rate of widely prescribed atypical antipsychotics when administered to newly admitted, acutely ill patients with schizophrenia or bipolar mania. METHODS: Medical records of patients admitted to psychiatric ward of two university hospitals between January 2007 and December 2008 were retrospectively reviewed. Subjects were eligible for inclusion if they prescribed olanzapine, risperidone or aripiprazole for their psychotic or manic symptom control. Patient groups (olanzapine/risperidone/aripiprazole) were compared for rate of antipsychotics discontinuation and duration of treatment continuation. RESULTS: There was no statistically significant difference in the rates of discontinuation during hospitalized period between olanzapine, risperidone and aripiprazole. Rates of discontinuation were 14.5% for olanzapine, 18.6% for aripiprazole and 24.0% for risperidone. Predictor of treatment discontinuation was short titration period and long illness duration. CONCLUSION: This study demonstrated that risperidone, olanzapine and aripiprazole were comparable with no difference found on the discontinuation rate in treating acutely ill psychiatric patients. However, the small number of patients who participated in this study made it difficult to establish significance.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Piperazinas
/
Esquizofrenia
/
Antipsicóticos
/
Benzodiazepinas
/
Transtorno Bipolar
/
Prontuários Médicos
/
Estudos Retrospectivos
/
Quinolonas
/
Risperidona
/
Aripiprazol
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Psychopharmacology
Ano de publicação:
2010
Tipo de documento:
Article