Changes of Urinary Prostaglandin in Male Patients with Lower Urinary Tract Symptoms

ABSTRACT

PURPOSE: Prostaglandin in the urinary bladder could be changed due to pathology of bladder and this change could be noted in the urine. This study was performed to investigate the changes in urinary prostaglandins in male patient with lower urinary tract symptom (LUTS). MATERIALS AND METHODS: The study groups included 60 male LUTS patients and 15 healthy male patients were used as the reference controls. Evaluation included history taking, urinalysis, IPSS and urodynamic study. The urinary concentration of prostaglandin E2 (PGE2) and prostaglandin F2alpha (PGF2alpha) in voided urine were analyzed by enzyme linked immunosorbent assay (ELISA) and these results were compared with control group. RESULTS: The IPSS scores of LUTS patients were higher than those of control patients. Also, detrusor overactivity was found in 30 patients and bladder outlet obstruction was found in 38 patients from urodynamic study. The urinary concentration of PGE2 was significantly increased in LUTS patients compared with control patients. The urinary concentration of PGF2alpha was not statistically significant between LUTS patients and control patients. The urinary concentration of PGE2 was decreased in LUTS patients with detrusor underactivity and negatively correlated to maximal bladder capacity. However, The urinary concentration of PGF2alpha was not correlated with IPSS and urodynamic parameters. CONCLUSION: Prostaglandins may play a role in lower urinary tract symptoms, and these changes can be detected in urine sample. Therefore, urinary PG may be used as a marker to evaluate lower urinary tract symptoms.