A study of association between the interleukin-1 single nucleotide polymorphism and risk of chronic periodontitis among the Hui and Dongxiang minorities in Gansu province / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 365-368, 2011.
Article
em Zh
| WPRIM
| ID: wpr-235043
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To examine and analyze the interleukin (IL)-1B gene single nucleotide polymorphism (SNP) at positions +3954, and explore the association between SNP and risk of chronic periodontitis (CP) among the Hui and Dongxiang minorities in Gansu province.</p><p><b>METHODS</b>CP group consisted of 215 patients from Hui and Dongxiang and healthy control group consisted of 219 subjects. Anti-coagulated peripheral blood sample was obtained from each subject and genomic DNA was extracted from each sample. SNP at IL-1B+3954 were analyzed by standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.</p><p><b>RESULTS</b>Statistically significant differences were found in genotype and allele frequencies between CP group and healthy control group. The exist of position alleles C increased the incidence of CP. The trend of frequency distribution of gene polymorphism above in Dongxiang was the same as that of Hui.</p><p><b>CONCLUSION</b>The present study reveals that IL-1B+3954C/T genotypes are significantly associated with the risk of CP. These results indicate that genetic polymorphism is significantly associated with the risk of CP among the Hui and Dongxiang minorities in Gansu province.</p>
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1
Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
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Polimorfismo de Fragmento de Restrição
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Reação em Cadeia da Polimerase
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Interleucina-1
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Alelos
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Periodontite Crônica
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Frequência do Gene
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Genótipo
Tipo de estudo:
Etiology_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
West China Journal of Stomatology
Ano de publicação:
2011
Tipo de documento:
Article