Salicylic acid derivatives as simplified and novel GK small molecule activators / 药学学报
Acta Pharmaceutica Sinica
; (12): 514-520, 2013.
Article
em Zh
| WPRIM
| ID: wpr-235635
Biblioteca responsável:
WPRO
ABSTRACT
Glucokinase (GK) is a new target for the treatment of type II diabetes mellitus (T2DM). In order to find a structure-simplified small molecule GK activator, 19 salicylic acid derivatives were designed and synthesized based on new lead compound (1). Experimental results showed that the potency of compound 8h is superior to control RO-28-0450 in GK activation.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Tiazóis
/
Desenho de Fármacos
/
Estrutura Molecular
/
Química
/
Salicilatos
/
Ativadores de Enzimas
/
Ativação Enzimática
/
Glucoquinase
/
Hipoglicemiantes
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2013
Tipo de documento:
Article