Relationship between expression of somatostatin receptors subtype 2 mRNA and estrogen and progesterone receptors in breast cancer / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1850-1853, 2003.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-235864
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To observe the expression of somatostatin receptor subtype 2 (SSTR2) mRNA, and investigate the relationship between the expression of SSTR2 mRNA and the expressions of estrogen and progesterone receptors (ERs and PRs) in benign and malignant breast tissues.</p><p><b>METHODS</b>Samples from a total of 23 breast carcinomas, 16 mammary hyperplasias, and 9 mammary fibroadenomas were analyzed. SSTR2 mRNA expression was examined by in situ hybridization using multiphase oligoprobes. ER and PR expressions were detected by immunohistochemical staining. A computerized image analysis system was utilized to estimate the relative content of SSTR2 mRNA.</p><p><b>RESULTS</b>The rate of expression (87.0%) and relative content (0.47) of SSTR2 mRNA in breast cancer were higher than those in benign breast tissue (64%, 0.26) (P < 0.05). SSTR2 mRNA expression was closely correlated with ER and PR expressions in breast cancer (P < 0.05). SSTR2 mRNA was also positively correlated with ER expression in benign breast tissues.</p><p><b>CONCLUSIONS</b>SSTR2 mRNA expression is higher or in benign breast tissues than in malignant ones. There is a significant positive correlation between SSTR2 mRNA and ER and PR expressions. Combined antiestrogen and somatostatin analogue in treatment of ER-positive breast cancers should be further investigated.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Mamárias
/
Neoplasias da Mama
/
RNA Mensageiro
/
Imuno-Histoquímica
/
Receptores de Progesterona
/
Receptores de Estrogênio
/
Química
/
Receptores de Somatostatina
/
Hibridização In Situ
/
Genética
Limite:
Humanos
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2003
Tipo de documento:
Artigo