Sub-endplate microcirculation disturbance directly contributes to intervertebral disc degeneration / 中华外科杂志
Chinese Journal of Surgery
; (12): 213-216, 2008.
Article
em Zh
| WPRIM
| ID: wpr-237816
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To build sub-endplate microcirculation disturbance animal model and to investigate the potential pathogenesis of intervertebral disc degeneration (IVDD).</p><p><b>METHODS</b>Twenty four New Zealand white rabbits were divided into treatment group (Group A) and control group (Group B). In Group A, animals received endotoxin and corticosteroid application to build sub-endplate microcirculation disturbance animal model, validated by microthrombus staining. In Group B, animals were given no drug, but standard feeding. After 3 month, the extent of IVDD was evaluated by the water content, biochemistry analysis, and morphology.</p><p><b>RESULTS</b>Sub-endplate microthrombus staining confirmed the exist of microcirculation disturbance. The water content and biochemistry components content of disc in Group A were lower than those of disc in Group B, and IVDD was observed in morphology.</p><p><b>CONCLUSION</b>Sub-endplate microcirculation disturbance can directly contribute to IVDD, the nutrients diffusion barrier is the potential pathogenesis of IVDD.</p>
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Base de dados:
WPRIM
Assunto principal:
Patologia
/
Trombose
/
Distribuição Aleatória
/
Modelos Animais de Doenças
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Disco Intervertebral
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Metabolismo
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Microcirculação
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Surgery
Ano de publicação:
2008
Tipo de documento:
Article