Studies on immunoregulation of polysaccharides-la from Radix Cynanchi Bungei / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1352-1355, 2005.
Article
em Zh
| WPRIM
| ID: wpr-239685
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of PRCB1a (one component of polysaccharides from Radix Cynanchi Bungei) on transformation of T lymphocytes of rabbit in vitro and immune function in mice.</p><p><b>METHOD</b>Three doses of PRCB1a (2,4,6 g x L(-1)) were respectively put in bottle with PHA and blood of rabbit. The effect of PRCB1a on immunity in vitro was studied by observing transformation of T lymphocytes; The dosage of PRCB1a (50,100,150 mg x kg(-1) x d(-1)) was given orally for seven days. The effects on immune function were investigated in mice.</p><p><b>RESULT</b>Three doses of PRCB1a could significantly promote (P < 0.01) the ability of T lymphocytes proliferation; PRCB1a could improve the mouse thymus and spleen index, the celiac macrophage ability of engulfing CRBC, the delayed type hypersensitivity ability and the macrophage engulfing carbon granula ability.</p><p><b>CONCLUSION</b>The results indicate PRCB1a can enhance nonspectific and specific cellular immune function.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Polissacarídeos
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Medicamentos de Ervas Chinesas
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Ativação Linfocitária
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Linfócitos T
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Distribuição Aleatória
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Química
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Adjuvantes Imunológicos
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Raízes de Plantas
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Cynanchum
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2005
Tipo de documento:
Article