The Predicting Factor of Vascular Endothelial Dysfunction in Healthy Premenopausal Obese Women
Journal of the Korean Academy of Family Medicine
; : 620-628, 2003.
Article
em Ko
| WPRIM
| ID: wpr-23972
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Vascular endothelial dysfunction (VED) plays a pivotal role in the pathogenesis of atherosclerosis and is associated with insulin resistance and with visceral obesity. Therefore, in this study the predicting factor of vascular endothelial dysfunction was investigated in healthy premenopausal obese women by pulse-wave analysis (PWA) combined with provocative pharmacological testing.METHODS:
Thirty three obese women (BMI> or =25), aged 20~45 y and 25 age-matched control subjects (BMI; 18.5~22.9) were examined. All women were sedentary (<1 hr/wk of physical activity), non-smoker and were excluded if they had type 2 diabetes melitus, hypertension, hyperlipidemia, cardiovascular disease, or acute inflammatory disease and were studied in folicullar phase of the cycle, within the first week after cessation of menstrual bleeding. They underwent determination of anthropometric measurements, metabolic variables, adipose tissue regional distribution, and endothelial function by performing pulse-wave analysis (PWA) combined with provocative pharmacological testing.RESULTS:
Augmentation Index (AIx) fell significantly after the administration of salbutamol, which causes endothelium-dependent vasodilatation, but response was significantly reduced in obese women compared with controls (10.28 6.72% vs 17.2 6.84%, P=0.0003). The change in after Nitroglycerin, which causes endothelium-independent vasodilatation, did not differ significantly (30.86 9.67% vs 30.6 10.11%, P=0.9172). In our obese subjects, visceral adipose tissue area was independently a significant predictor of vascular endothelial dysfunction (beta= 0.1381, P=0.0038, Adj-R2=0.348).CONCLUSION:
Increased abdominal adiposity is a powerful independent predictor of VED in obese healthy women. Future studies of vascular endothelial function should account for the independent effects of abdominal fat.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Vasodilatação
/
Resistência à Insulina
/
Doenças Cardiovasculares
/
Tecido Adiposo
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Nitroglicerina
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Albuterol
/
Gordura Abdominal
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Gordura Intra-Abdominal
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Aterosclerose
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Adiposidade
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
Ko
Revista:
Journal of the Korean Academy of Family Medicine
Ano de publicação:
2003
Tipo de documento:
Article