Antitumor components screening of Stellera chamaejasme L. under the case of discrete distribution of active data / 药学学报
Acta Pharmaceutica Sinica
; (12): 927-931, 2014.
Article
em Zh
| WPRIM
| ID: wpr-244993
Biblioteca responsável:
WPRO
ABSTRACT
This is to report the screening, extracting and validating antitumor components and compounds from Stellera chamaejasme L. under the case of discrete distribution of active data. In this work, different components from Stellera chamaejasme L. were collected by HPD macroporous resin and polyamide resin column, and their antitumor activity on A549 were tested by MTT assay. Activity results indicate that activity of components at 30-39 min is more potent than that of Stellera chamaejasme L. extract, and the activity of components at 33.97 min is equivalent to positive drug, cis-platinum at 100 microg x mL(-1), but with totally different mode of action. Under the case of discrete activity, the weight analysis is capable of screening active components and compounds from natural products.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Ensaios de Seleção de Medicamentos Antitumorais
/
Química
/
Thymelaeaceae
/
Linhagem Celular Tumoral
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Article