FGF-21 protects H9c2 cardiomyoblasts against hydrogen peroxide-induced oxidative stress injury / 药学学报
Acta Pharmaceutica Sinica
; (12): 470-475, 2014.
Article
em Zh
| WPRIM
| ID: wpr-245060
Biblioteca responsável:
WPRO
ABSTRACT
Fibroblast growth factor-21 (FGF-21) is an important metabolism regulator, however, whether FGF-21 has effects on cardiovascular remains unclear. In this study, H2O2-induced injury in H9c2 cells was used as a cell model, the anti-apoptosis potential and mechanism of FGF-21 against oxidative injury were evaluated by MTT assay, flow cytometry assay and real-time PCR. The results showed that FGF-21 could increase the cell survival of H2O2-induced injury in H9c2 cells and prevent H9c2 cells from oxidative stress-induced apoptosis. Furthermore, FGF-21 can elevate SOD activity and regulate Bcl-2/Bax expression in H9c2 cells. The results suggest that FGF-21 have protective effect against the H2O2-induced apoptosis in H9c2 cells.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
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Superóxido Dismutase
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RNA Mensageiro
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Células Cultivadas
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Espécies Reativas de Oxigênio
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Apoptose
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Estresse Oxidativo
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Proteínas Proto-Oncogênicas c-bcl-2
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Substâncias Protetoras
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Biologia Celular
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2014
Tipo de documento:
Article