Association of CASP3 polymorphisms and its haplotypes with susceptibility of breast cancer / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the association of Caspase3 (CASP3) polymorphisms with susceptibility of breast cancer in Chinese Han population.</p><p><b>METHODS</b>In this population-based case-control study, 251 cases with breast cancers and 251 matched controls in terms of habitation and age (±5 years) were recruited. Rs4647693, rs2696056, rs4647610 were selected as TagSNPs in CASP3 gene and genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The haplotype distribution was estimated and compared by PHASE software.</p><p><b>RESULT</b>There was significant association between menarche age and breast cancer (P=0.007), as well as the early pregnancy age and breast cancer (P=0.002). No significant differences were detected in the distribution of CASP3 genotype and haplotype frequencies between breast cancer patients and controls. The GGA was the most common haplotype both in cases and controls.</p><p><b>CONCLUSION</b>CASP3 polymorphisms and its haplotypes were not related to the susceptibility of breast cancer.</p>