Relationship between single nucleotide polymorphisms of paraoxonase 2 and stroke / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the relationship between single nucleotide polymorphisms of paraoxonase 2 (PON2) and stroke.</p><p><b>METHODS</b>Objects examined comprised of three groups: 120 healthy people, 150 patients with cerebral hemorrhage, 180 patients with cerebral infarction. The PON2 genotypes were determined with PCR and digested by specific restriction enzymes.</p><p><b>RESULTS</b>C311S and G148A polymorphisms of PON2 gene existed among population of Chinese Hunan area, with the allele frequencies 0.23/0.77 for C/S and 0.57/0.43 for G/A in the control group. There was no significant difference of genotype and allele frequency between stroke patients and controls (P>0.05).</p><p><b>CONCLUSION</b>C311S polymorphism of PON2 has no significant correlation with stroke in Han people of Chinese Hunan area and allele C/S is not an independent risk factor for stroke,neither is G148A.</p>