Association between type 2 diabetes mellitus and risk of cancers: a cohort study / 中华流行病学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To understand the association between type 2 diabetes and the risk of cancers.</p><p><b>METHODS</b>Data related to type 2 diabetes mellitus (T2DM) cases and cancer cases were collected from Zhejiang Chronic Disease Surveillance Information and Management System (CDSIMS) , between January 1, 2007 and December 31, 2013. Cumulative incidence and relative risk (RR) with 95% confidence interval (CI) were calculated.</p><p><b>RESULTS</b>From 2007 to 2013, a total of 327 268 T2DM and 7 435 cancer cases were respectively reported and 778 439 person-years completed the followed-up program. Among the T2DM patients, incidence of cancers was 955.12 per 100 000, with standardized incidence as 458.05 per 100 000. Compared with people without T2DM, the risk of cancer incidence increased in T2DM patients (RR=1.68, 95%CI 1.68-1.70). Risk appeared the highest in 20-39 year age group but decreased when the increase of age. In addition, the increased risk was still significant in T2DM patients aged ≥60 years (RR=1.21, 95%CI 1.18-1.25).</p><p><b>CONCLUSION</b>Results from the study suggested that T2DM was associated with the increased risk of cancers, statistically.</p>