Multiple risk factor clustering and risk of hypertension in the Mongolian ethnic population of China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 381-385, 2007.
Article
em En
| WPRIM
| ID: wpr-249839
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate whether the clustering of risk factors, both environmental and genetic, increases the risk of essential hypertension (EH) and the accumulation of risk factors influences the blood pressure level in normotensives.</p><p><b>METHODS</b>On the basis of a prevalence survey, 501 subjects of Mongolian ethnicity (243 hypertensives and 258 normotensives) who were not related to each other were selected to conduct a case-control study. All subjects were interviewed with questionnaires and their blood specimens were collected. Renin gene insertion/deletion (I/D) polymorphism, a new genetic marker, was genotyped with PCR and polyacrylamide gel electrophoresis.</p><p><b>RESULTS</b>Overweight, alcohol consumption, and renin gene I/D polymorphism were significant risk factors of EH (P<0.05). The odds ratios (OR) for the number of risk factors were 2.39 (95%CI 0.98-6.74) for one risk factor, 5.03 (95%CI 2.06-14.18) for two, and 6.09 (95%CI 1.85-22.38) for three respectively after adjusting for age and sex. In normotensives, age- and sex-adjusted mean blood pressures increased with more accumulation of risk factors. However, there were no significant differences among the different blood pressure levels according to the number of risk factors (P>0.05).</p><p><b>CONCLUSION</b>Overweight, alcohol consumption, and renin gene I/D polymorphism are risk factors of EH in the Mongolian ethnic population of China. The accumulation of the risk factors causes a sharp increase of the risk of EH.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Análise por Conglomerados
/
Razão de Chances
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China
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Epidemiologia
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Fatores de Risco
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Etnologia
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Hipertensão
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Mongólia
Tipo de estudo:
Etiology_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2007
Tipo de documento:
Article