Synthesis of a novel starch derivative and its adsorption property for creatinine / 药学学报
Acta Pharmaceutica Sinica
; (12): 191-195, 2003.
Article
em Zh
| WPRIM
| ID: wpr-251145
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To prepare a novel creatinine adsorbent with anti-renal failure activity.</p><p><b>METHODS</b>A novel starch ester was prepared under heterogeneous condition by the reaction of starch (ST) and 3, 5-dinitrobenzoyl chloride (DNBZ-Cl). The products were characterized by means of elemental analysis, FTIR, 13CNMR and UV-Vis spectra. The adsorption properties of DNBZ-ST were examined.</p><p><b>RESULTS</b>The adsorption equilibrium is reached after 4 h, the adsorption capacity increases with the degree of substitution (DS) of adsorbent and creatinine concentration. When creatinine concentration is higher than 300 mg.L-1, concentration showed no apparent effect on adsorption capacity. As the adsorption temperature varied from 19 degrees C to 49 degrees C, adsorption capacity first decreases and then increases, and is lowest at 37 degrees C. The adsorption capacity first increases and then decreases as the pH value increase from 4 to 11 and is highest at pH 8. The highest adsorption capacity reached 25 mg.g-1 at 37 degrees C pH 7 and the creatinine concentration is 100 mg.L-1.</p><p><b>CONCLUSION</b>Starch 3,5-dinitrobenzoate showed a better adsorption property for creatinine, and it is worthy to be studied more deeply.</p>
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Base de dados:
WPRIM
Assunto principal:
Amido
/
Espectroscopia de Ressonância Magnética
/
Química
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Espectroscopia de Infravermelho com Transformada de Fourier
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Adsorção
/
Creatinina
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Nitrobenzoatos
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2003
Tipo de documento:
Article