Advance on genetic mechanism of adolescent idiopathic scoliosis and genetic relationship map / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 854-860, 2015.
Article
em Zh
| WPRIM
| ID: wpr-251625
Biblioteca responsável:
WPRO
ABSTRACT
Identification of genetic risk factors is the hotspot of adolescent idiopathic scoliosis (AIS). Through candidate gene approach and genome-wide association studies (GWAS), some genes were preliminary identified. To review AIS related genes,and construct the gene network map of AIS gene. We searched on NCBI PubMed and Web of Science database using search terms "adolescent idiopathic scoliosis" and "gene", to classify induction genes. We then constructed gene diagram using string-db. We found 35 AIS genes relating to connective tissue, nervous system active substances, melatonin synthesis and metabolism, puberty and growth, and genes whose function is unknown. Gene diagram shows that a network relationship between gene and other genes,in which IL6, ESR1, ESR2, VDR, TGFB1, IGF1 gene may as the key gene about AIS' genetic mechanism. Two sites of 3 GWAS results outside the network, it is suggesting new pathway that need to be explored. The study about AIS susceptibility gene is still preliminary, requiring in-depth research to identify the new networks.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Escoliose
/
Fator de Crescimento Insulin-Like I
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Predisposição Genética para Doença
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Fator de Crescimento Transformador beta1
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Estudo de Associação Genômica Ampla
/
Proteínas Matrilinas
/
Genética
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Humans
Idioma:
Zh
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2015
Tipo de documento:
Article