Characterization of a novel impurity in bulk drug of lisinopril by multidimensional NMR technique / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
; (12): 310-313, 2006.
Article
em En
| WPRIM
| ID: wpr-251920
Biblioteca responsável:
WPRO
ABSTRACT
During the routine impurity profile of lisinopril bulk drug by HPLC (high-performance liquid chromatography), a potential impurity was detected. Using multidimensional NMR (nuclear magnetic resonance) technique, the trace-level impurity was unambiguously identified to be 2-(-2-oxo-azocan-3-ylamino)-4-phenyl-butyric acid after isolation from lisinopril bulk drug by semi-preparative HPLC. Formation of the impurity was also discussed. To our knowledge, this is a novel impurity and not reported elsewhere.
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Base de dados:
WPRIM
Assunto principal:
Butiratos
/
Espectroscopia de Ressonância Magnética
/
Modelos Moleculares
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Contaminação de Medicamentos
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Lisinopril
Idioma:
En
Revista:
Journal of Zhejiang University. Science. B
Ano de publicação:
2006
Tipo de documento:
Article