Comparison of acute toxicity of extract of unprocessed indian atringbush root and its two different processed products / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1172-1174, 2011.
Article
em Zh
| WPRIM
| ID: wpr-252888
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To compare the acute toxicity and content of daphnoretin among extracts of unprocessed indian string-bush root and its two different processed products, and to provide a basis for discussion of the mechanism of two processed methods.</p><p><b>METHOD</b>Extracts of unprocessed indian stringbush root and processed indian stringbush root with "sweat" and "artificial sweat" were prepared. The mice were intragastrically administrated once with these three extracts, the mortalities of mice were observed, and the median lethal dose (LD50) of different extracts were calculated with Bliss method. The determination of daphnoretin in these three samples was performed by high performance liquid chromatography.</p><p><b>RESULT</b>The LD50 of indian stringbush root extracts, indian stringbush root processed with "sweat" and with "artificial sweat" were 46.678, 72.190, 67.953 g x kg(-1), respectively. The contents of daphnoretin in unprocessed indian stringbush root, indian stringbush root processed with "sweat" and with "artificial sweat" were 0.189%, 0.407% and 0.345%, respectively.</p><p><b>CONCLUSION</b>The toxicity of indian stringbush root processed with both "sweat" and "artificial sweat" is lower than that of the original rude drug. But the decreasion of toxicity of processed products is not by the reduced daphoretin content.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Extratos Vegetais
/
Química
/
Cromatografia Líquida de Alta Pressão
/
Testes de Toxicidade
/
Raízes de Plantas
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Cumarínicos
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Wikstroemia
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Toxicidade
/
Dose Letal Mediana
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2011
Tipo de documento:
Article