Research progress on epithelial-mesenchymal transition in cancer recurrence and metastasis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 211-216, 2015.
Article
em Zh
| WPRIM
| ID: wpr-255209
Biblioteca responsável:
WPRO
ABSTRACT
Epithelial-mesenchymal transition (EMT) is a process in which epithelial cells lose their morphology and function and gradually transformed into mesenchymal-like cells. It is considered that EMT is the main cause for tumor recurrence and metastasis. Many factors are involved in the regulation of EMT, such as E-cadherin, transforming growth factor-β, Wnt signaling pathway, microRNA and EMT-related transcription factors. This article reviews the research progress on EMT and the involved mechanisms, and thus to provide a new perspective on cancer therapy in the future.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fatores de Transcrição
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Transdução de Sinais
/
Caderinas
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Fator de Crescimento Transformador beta
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MicroRNAs
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Transição Epitelial-Mesenquimal
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Via de Sinalização Wnt
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Metástase Neoplásica
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Recidiva Local de Neoplasia
/
Neoplasias
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2015
Tipo de documento:
Article