Correlation between follicle-stimulating hormone and total procollagen I N-terminal propeptide in perimenopausal women / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 85-89, 2015.
Article
em Zh
| WPRIM
| ID: wpr-255229
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between serum levels of follicle-stimulating hormone (FSH) and total procollagen I N-terminal propeptide (TP1NP) in perimenopausal women.</p><p><b>METHODS</b>Total 274 women aged 33~60 y with perimenopausal period were enrolled in this study. Serum levels of FSH and TP1NP were detected by electrochemiluminescence.</p><p><b>RESULTS</b>In 274 perimenopausal women, the average level of TP1NP was (48.99±20.31) ng/mL, which was positively correlated with FSH level (r=0.159, P=0.009). In 40-50 age group, TP1NP level in women with FSH<40 mIU/mL was lower than that in those with FSH≥40mIU/mL [(35.05±18.11) ng/mL vs (51.33±24.67) ng/mL; t=-2.954, P=0.004]. However, in <40 and 50-60 age groups, there were no significant differences in TP1NP levels between patients with FSH<40 mIU/mL and those with FSH≥40 mIU/mL (t=-0.063, P=0.950; t=1.177, P=0.242). Multiple linear regression analysis showed that standardized coefficients of age variable was 0.047 (P=0.448) and standardized coefficients of FSH variable was 0.146 (P=0.019).</p><p><b>CONCLUSION</b>TP1NP levels showed a certain correlation with FSH in perimenopausal women, especially for women aged 40-50, indicating that high FSH levels may be important factors for osteoporosis in postmenopausal women.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fragmentos de Peptídeos
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Sangue
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Pró-Colágeno
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Perimenopausa
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Hormônio Foliculoestimulante
Limite:
Adult
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Female
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Humans
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2015
Tipo de documento:
Article