Mechanisms of the role of fibroblast growth factor 21 in attenuating insulin resistance / 药学学报
Acta Pharmaceutica Sinica
; (12): 1101-1106, 2015.
Article
em Zh
| WPRIM
| ID: wpr-257021
Biblioteca responsável:
WPRO
ABSTRACT
This study is to evaluate the therapeutic effect of fibroblast growth factor 21 (FGF21) on type 2 diabetic mice model and to provide mechanistic insights into its therapeutic effect. Type 2 diabetic animal model was established with high calorie fat diet and low dose streptozotocin (STZ) injection. Mice were then randomized into 5 groups: model control, FGF21 0.25 and 0.05 μmol x kg(-1) x d(-1) groups, insulin treatment group. Ten age-matched normal KM mouse administered with saline were used as normal controls. Serum glucose, insulin, lipid products and the change of serum and liver tissue inflammation factor levels between five groups of mouse were determined. The results showed that blood glucose, insulin, free fatty acids (FFAs), triglycerides, and inflammatory factor average FGF-21 of type 2 diabetes model group and normal control group were significantly higher (P < 0.01), while compared with insulin group, no difference was significant. Average blood glucose, insulin, blood lipid and inflammatory factor of FGF-21 treatment group compared with type 2 diabetes group was significantly lower (P < 0.01) and insulin group has no difference with the model control group. The results of OGTT and HOMA-IR showed that insulin resistance state was significantly relieved in a dose-dependent manner. Thus, this study demonstrates that FGF-21 significantly remits type 2 diabetic mice model's insulin resistance state and participates in the regulation of inflammatory factor levels and type 2 diabetes metabolic disorders.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Triglicerídeos
/
Sangue
/
Glicemia
/
Resistência à Insulina
/
Estreptozocina
/
Diabetes Mellitus Experimental
/
Diabetes Mellitus Tipo 2
/
Tratamento Farmacológico
/
Ácidos Graxos não Esterificados
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2015
Tipo de documento:
Article