The Epidemiological Characteristics of Beijing Lineage Mycobacterium tuberculosis from a National Referral Center in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 539-543, 2015.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-264549
Biblioteca responsável:
WPRO
ABSTRACT
Our study was to investigate the epidemiological characteristics of M.tuberculosis from a national tuberculosis referral center in China. All strains isolated from TB patients, were genotyped by the RD105 deletion, 8 and 51 SNP loci and VNTR. The high differentiation SNPs of modern Beijing strains were analyzed for protein function and structure. 413 M. tuberculosis were included. Of 379 Beijing lineage M. tuberculosis, 'modern' and 'ancient' strains respectively represented 85.5% (324/379) and 14.5% (55/379). Rv2494 (V48A) and Rv0245 (S103F) were confirmed as high differentiation SNPs associated with modern strains. In a word, Modern Beijing lineage M.tuberculosis was dominant and the structural models suggested that modern sub-lineage may more easily survive in 'extreme' host condition.
Texto completo:
Disponível
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Tuberculose
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Filogenia
/
Tuberculose
/
DNA Bacteriano
/
China
/
Epidemiologia
/
Classificação
/
Genoma Bacteriano
/
Epidemiologia Molecular
/
Polimorfismo de Nucleotídeo Único
/
Filogeografia
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Biomedical and Environmental Sciences
Ano de publicação:
2015
Tipo de documento:
Artigo