Experimental study on effect and mechanism of soybean protease inhibitor on endotoxin-induced acute lung injury / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1451-1454, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-264857
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effect of soybean protease inhibitor on LPS-induced lung injury in rats.</p><p><b>METHOD</b>Fifty male SD rats were randomly divided in five groups, 10 rats in each group as sham-operation group, model control group, positive medicine group, and high, moderate SBTI groups. Except the sham-group, other groups were induced by intratracheal instillation of LPS with a dose of 6 mg x kg(-1). All rats were given drug throughout intraperitoneal injection except the model controlled group, the positive medicine group was given PMSF with a dose of 50 mg x kg(-1), the high dose group of SBTI was given SBTI with a dose of 100 mg x kg(-1), a dose of the moderate group is 50 mg x kg(-1). We examined all rats in seven days. Index exam cell quantity, activity of neutrophilic granulocyte released elastic protease proteins in BALF, histopathological examination and so on.</p><p><b>RESULT</b>Soybean protease inhibitor can level down the level of total protein, cell quantity, PMN percent, activity of neutrophilic granulocyte in BALF. SBTI level down the content of NF-kappa B in nucleoprotein, while increase the content of I kappa B alpha in plasmoprotein.</p><p><b>CONCLUSION</b>SBTI is useful in protecting experimental pulmonary injury induced by LPS in rats.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Farmacologia
/
Glycine max
/
Química
/
Inibidores da Tripsina
/
Proteínas I-kappa B
/
Tratamento Farmacológico
/
Endotoxinas
/
Fator de Transcrição RelA
/
Toxicidade
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Artigo