Methodological study on quality evaluation of rhubarb based on purgative bioassay / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1309-1312, 2008.
Article
em Zh
| WPRIM
| ID: wpr-264915
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To establish a method suitable to determine the purgative biopotency of rhubarb and construct a new quality evaluation pattern of rhubarb.</p><p><b>METHOD</b>A series of factors such as observation index (mass of feces in 10 hours), animal strain (ICR mice), sex (male) and the dose of diphenoxylate complex (50 mg x kg(-1)) was investigated and fixed. The purgative biopotency as well as anthraquinone determination was used to evaluate the quality of different rhubarb samples.</p><p><b>RESULT</b>There wasn't a good linear relationship between the purgative biopotency and content of anthraquinone. The quality difference of rhubarb samples could be well characterized by combination of purgative biopotency determination and anthraquinone determination.</p><p><b>CONCLUSION</b>The purgative biopotency determination can be used in quality control and evaluation of rhubarb.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
Controle de Qualidade
/
Rheum
/
Fatores de Tempo
/
Bioensaio
/
Medicamentos de Ervas Chinesas
/
Catárticos
/
Modelos Lineares
/
Química
/
Fatores Sexuais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2008
Tipo de documento:
Article