Extraction of lobetyolin from codonopsis with supercritical CO2 / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 560-563, 2009.
Article
em Zh
| WPRIM
| ID: wpr-265383
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To develop a green and rapid method for extraction of lobetyolin from C. pilosula.</p><p><b>METHOD</b>Extraction of lobetyolin from C. pilosula with supercritical carbon dioxide in the presence of ethanol was studied. The effects of pressure, temperature, volume of cosolvent and extraction time on efficiency and their interactive relationships were discussed, based on central composite design and response surface methodology (RSM).</p><p><b>RESULT</b>The key effect factor was volume of cosolvent. The extraction yield of lobetyolin was 0.078 6 mg x g(-1) when C. pilosula (40-60 mesh) was extracted at 30 MPa, 60 degrees C and 2 L x min(-1) (as CO2 in normal pressure and temperature) for 100 minutes with supercritical CO2 and 1 mL x min(-1) ethanol as dynamic cosolvent.</p><p><b>CONCLUSION</b>This result is better than that obtained from traditional method. Therefore, the optimized process is valuable for extraction of lobetyolin from C. pilosula.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Dióxido de Carbono
/
Medicamentos de Ervas Chinesas
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Química
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Codonopsis
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Etanol
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Fracionamento Químico
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Polímero Poliacetilênico
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Métodos
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2009
Tipo de documento:
Article