Detection of serum autoantibodies against AT₁A-receptor during the development of the four types of hypertensive rat models / 生理学报
Acta Physiologica Sinica
; (6): 90-94, 2006.
Article
em En
| WPRIM
| ID: wpr-265481
Biblioteca responsável:
WPRO
ABSTRACT
Using two-kidney one-clip renal hypertensive (2K1C group), stress-induced hypertensive (neural group), DOCA-salt treated hypertensive (DOCA group) and spontaneously hypertensive rats (SHR group), to investigate the change in AT(1A)-receptor autoantibodies (AT(1A)-AAs) during the development of the four types of hypertension. The biological activities of AT(1A)-AAs were examined. It was shown that the frequency of occurrence and titres of AT(1A)-AAs increased significantly during the development of hypertension. In the four hypertensive groups studied, the occurrence of AT(1A)-AAs was most prominent in SHR, 2K1C and neural groups. The biological effects of AT(1A)-AAs were shown to increase the beating frequency of cultured neonatal myocardial and vascular contractile tension. It is suggested that autoimmune mechanisms are involved the pathogenesis of different types of hypertension and the AT(1A)-AAs may be one of the mechanisms leading to cardiac hypertrophy.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Fisiologia
/
Ratos Endogâmicos SHR
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Ratos Endogâmicos WKY
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Autoanticorpos
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Estresse Fisiológico
/
Sangue
/
Classificação
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Ratos Wistar
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Receptor Tipo 1 de Angiotensina
/
Desoxicorticosterona
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Acta Physiologica Sinica
Ano de publicação:
2006
Tipo de documento:
Article