Microinjection of NMDA-type glutamate receptor agonist NMDA and antagonist D-AP-5 into the central nucleus of the amygdale alters water intake rather than food intake / 南方医科大学学报
Journal of Southern Medical University
; (12): 595-600, 2012.
Article
em En
| WPRIM
| ID: wpr-267543
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of N-Methyl-D-aspartic acid (NMDA)-type glutamate receptors in the central nucleus of the amygdale (CeA) in food and water intake.</p><p><b>METHODS</b>Male Sprague-Dawley rats with stainless steel cannulae implanted unilaterally into the CeA were used. The prototypic NMDA receptor agonist NMDA, or the selective NMDA receptor antagonist D(-)-2-amino-5-phosphonopentanoic acid (D-AP-5) was microinjected into the CeA of satiated and euhydrated rats.</p><p><b>RESULTS</b>Intra-CeA injection of 8.50, 17.00, or 34.00 nmol NMDA did not alter food intake but significantly increased water intake 0-1 h after the injection (F(3,32)=3.191, P=0.037) independent of food intake. Without affecting the food intake, injection of 6.34, 12.70, or 25.40 nmol D-AP-5 into the CeA significantly decreased water intake 0-1 h after the injection (F(3,28)=3.118, P=0.042) independent of food intake.</p><p><b>CONCLUSION</b>NMDA receptors in the CeA may participate in the control of water intake rather than food intake.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
2-Amino-5-fosfonovalerato
/
N-Metilaspartato
/
Ratos Sprague-Dawley
/
Receptores de N-Metil-D-Aspartato
/
Antagonistas de Aminoácidos Excitatórios
/
Agonistas de Aminoácidos Excitatórios
/
Ingestão de Líquidos
/
Ingestão de Alimentos
/
Tonsila do Cerebelo
Limite:
Animals
Idioma:
En
Revista:
Journal of Southern Medical University
Ano de publicação:
2012
Tipo de documento:
Article