Clinical analysis of 17 cases of Gitelman syndrome / 南方医科大学学报
Journal of Southern Medical University
; (12): 432-434, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-267582
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the clinical and laboratory characteristics of Gitelman syndrome.</p><p><b>METHODS</b>Seventeen patients with Gitelman syndrome (male/female 11/6) were analyzed for their clinical symptoms, laboratory test results, imaging findings, treatments and outcomes.</p><p><b>RESULTS</b>Fifteen of the 17 patients presented with varying degrees of lower limb weakness, and 8 experienced flaccid paralysis. The laboratory tests showed hypokalemia (17/17), hypomagnesemia (17/17) and hypocalcemia (17/17). Blood renin activity (17/17), angiotensin II (14/17) and aldosterone levels (7/17) were significantly higher in the patients than in normal subjects. The symptoms were relieved by potassium alone or in combination with indomethacin, spironolactone and other potassium magnesium asparaginate, but the serum potassium and magnesium failed to recover the normal levels after the treatments.</p><p><b>CONCLUSION</b>The primary clinical manifestations of Gitelman syndrome are lower extremity weakness with hypokalemia and hypomagnesemia. Combined drug therapies including potassium, magnesium, aldosterone antagonists and other drugs are recommended. The prognosis of the patients is favorable.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cloreto de Potássio
/
Aspartato de Magnésio e Potássio
/
Espironolactona
/
Indometacina
/
Estudos Retrospectivos
/
Usos Terapêuticos
/
Diagnóstico
/
Tratamento Farmacológico
/
Síndrome de Gitelman
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2012
Tipo de documento:
Artigo