Analysis of anisodine and its metabolites in rat plasma by liquid chromatography-tandem mass spectrometry / 药学学报
Acta Pharmaceutica Sinica
; (12): 518-521, 2006.
Article
em Zh
| WPRIM
| ID: wpr-271415
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To identify anisodine and its metabolites in rat plasma after ingestion of anisodine by combining liquid chromatography and tandem mass spectrometry (LC-MS(n)).</p><p><b>METHODS</b>Plasma samples from rats after a single orally administration of 20 mg anisodine were added with methanol to precipitate protein. Then, it was analyzed by LC-MS(n). Identification and structural elucidation of the metabolites were performed by comparing their changes in molecular masses, retention-times and full scan MS(n) spectra with those of the parent drug and blank plasma.</p><p><b>RESULTS</b>The results revealed that the parent drug and its four metabolites (norscopine, scopine, hydroxyanisodine, N-oxide anisodine) existed in rat plasma.</p><p><b>CONCLUSION</b>This method is sensitive, rapid, simple, and it is suitable for the rapid identification of drug and its metabolits.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Plantas Medicinais
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Derivados da Escopolamina
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Química
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Administração Oral
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Cromatografia Líquida
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Sensibilidade e Especificidade
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Ratos Wistar
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Solanaceae
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Espectrometria de Massas em Tandem
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Metabolismo
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2006
Tipo de documento:
Article