Genomic Instability in Acute Transformation of Chronic Myelogenous Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1199-1202, 2015.
Article
em Zh
| WPRIM
| ID: wpr-274066
Biblioteca responsável:
WPRO
ABSTRACT
Chronic myeloid leukemia (CML) is a myeloproliferative disorder, characterized by excessive proliferation of myeloid cells. CML patients in early phase [also known as chronic phase (CP)] usually respond to treatment with tyrosine kinase inhibitors (TKI), some patients respond initially to TKI, but later become resistant, then resulting in the transformation from CP to more advanced phase, which were subclassified as either accelerated phase or blastic phase. At present, the molecular mechanisms of CML have been not yet clear, and acute transformation has been not fully understood, studies have shown that genomic instability promotes the acute conversion of CML. This review discusses the molecular mechanisms leading to the transformation of CML, and some therapeutic approaches.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Crise Blástica
/
Resistencia a Medicamentos Antineoplásicos
/
Instabilidade Genômica
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2015
Tipo de documento:
Article