Research on the extracorporeal cytocompatibility of a composite of HA, carbon fiber and polyetheretherket-one / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 1159-1164, 2011.
Article
em Zh
| WPRIM
| ID: wpr-274934
Biblioteca responsável:
WPRO
ABSTRACT
The present research was to study the biocompatibility of a composite of hydroxyapatite (HA), carbon fiber (CF) and polyetheretherket-one (PEEK) by co-culturing with the osteoblasts in vitro. Cell relative growth (RGR) was used as a quantitative assessment for cytotoxicity of the biomaterials by CCK-8. The proliferation index of the co-cultured cells and ALP activity was measured to study the effect of PEEK-HA-CF composites. Morphological properties of the osteoblast cells in vitro were observed by scanning electro-microscopy (SEM). The PEEK-HA-CF materials have no cytotoxicity to osteoblasts. The proliferation index of PEEK-HA-CF was higher than that of Ti alloy group, but these was no significant difference compared to that of control group. The ALP activity was the highest on PEEK-HA-CF composites surface after 7 days. The osteoblast cells co-cultured with the PEEK-HA-CF composite were adhered well to the biomaterial as observed under the SEM. The results suggested that the PEEK-HA-CF composites had good biocompatibility in vitro and might be a novel orthopedic implanted material.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Ortopedia
/
Osteoblastos
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Polietilenoglicóis
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Próteses e Implantes
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Materiais Biocompatíveis
/
Carbono
/
Células Cultivadas
/
Química
/
Durapatita
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Proliferação de Células
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2011
Tipo de documento:
Article