Studies on the anti-inflammation effect of the TCM prescription of a combination of monkshood root with peony root / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To make a comparison between the single and combined use of Monkshood Root and Peony Root to observe the anti-inflammation effect in the experimental animals.</p><p><b>METHOD</b>The experimental inflammatory models were adopted, i.e. adjuvant-induced polyarthritis carrageenan-induced or formaldehyde-induced rat paw edema, and cotton pellet-induced granuloma formation in rats xylene-induced mouse ear edema, exudation of abdominal blood capillaries of mice, etc.</p><p><b>RESULT</b>The anti-inflammafion effect of Monkshood Root was weaker than that of Peony Root or Peony Root combined with Monkshood Root. It was found that anti-inflammation effect with the drug-cooperation was enhanced more significantly in the formaldehyde-induced or adjuvant-induceed arthritis models than in the carrageenan-induced rat paw edema and other inflammatory models either in the large dosage of 11 proportion or in the small dosage of 12 proportion.</p><p><b>CONCLUSION</b>The drug-cooperation has a good selective and synergic effect on anti-inflammation.</p>