Neuroprotective effect of longistyline A against corticosterone-induced neurotoxicity in PC12 cells / 药学学报
Acta Pharmaceutica Sinica
; (12): 600-603, 2012.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-276274
Biblioteca responsável:
WPRO
ABSTRACT
This study is to investigate the protective effect of longistyline A against corticosterone-induced neurotoxicity in PC12 cells. While PC12 cells were exposed to 100 micromol x L(-1) corticosterone for 48 h, cell survival rate was reduced and lactate dehydrogenase (LDH) release increased. In parallel, corticosterone caused significant elevations of DNA fragmentation, [Ca2+]i and caspase-3 activity. However, when the PC12 cells were incubated with longistyline A (4.0, 8.0 and 16.0 micromol x L(-1)) in the presence of 100 micromol x L(-1) corticosterone for 48 h, the effects were evidently alleviated, but dose-dependent manner was not obvious. In summary, longistyline A could generate a neuroprotective effect against corticosterone-induced neurotoxicity in PC12 cells possibly by decreasing [Ca2+]i and caspase-3 activity.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Fenóis
/
Plantas Medicinais
/
Corticosterona
/
Estrutura Molecular
/
Sobrevivência Celular
/
Química
/
Cálcio
/
Células PC12
/
Folhas de Planta
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2012
Tipo de documento:
Artigo