Polymorphism of HLA-A,-B and DRB1 in Han population of Shanxi province / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 583-584, 2005.
Article
em Zh
| WPRIM
| ID: wpr-279993
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the polymorphism of HLA-A, -B, -DRB1 genes in Han population in Shanxi of China.</p><p><b>METHODS</b>Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used to identify the polymorphism of HLA-A, -B, -DRB1 genes of 7440 healthy and unrelated individuals of Han population in Shanxi, and the gene frequency distribution of HLA-A, -B, -DRB1 genes in population was compared with the results from other populations.</p><p><b>RESULTS</b>Eighteen HLA-A, forty HLA-B and thirteen HLA-DRB1 alleles were found. The frequencies of A*02, A*24, A*11, A*01, A*03, B*13, B*51, B*15, B*40, B*35, DRB1*15, DR*09, DR*12, DR*04, DR*07 alleles in Hans of Shanxi were significantly higher and displayed distinctive distribution profiles when compared with those of Caucasian and Afro-American.</p><p><b>CONCLUSION</b>The HLA-A,-B,-DRB1 distribution in Shanxi Han population shares some genetic characteristics with other Han populations in northern part of China, but it exhibits its own characteristics.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
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Antígenos HLA-A
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Antígenos HLA-B
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Antígenos HLA-DR
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China
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Reação em Cadeia da Polimerase
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Povo Asiático
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Cadeias HLA-DRB1
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Frequência do Gene
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Genética
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2005
Tipo de documento:
Article