Frequency of prothrombin gene G20210A variant in the 3'-untranslated region in Zhuang ethnic Chinese / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 341-343, 2005.
Article
em Zh
| WPRIM
| ID: wpr-280054
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To ascertain the frequency of prothrombin (FII) gene 3'-untranslated region (3'-UT) G20210A variant and to explore whether this mutation is related to arterial thrombosis in Chinese Zhuang population.</p><p><b>METHODS</b>Seventy-six patients with cerebral thrombosis, 23 patients with myocardial infarction and 106 healthy Chinese Zhuang persons were studied. The G20210A mutant allele of the prothrombin gene in all blood specimens was investigated by DNA extraction, polymerase chain reaction amplification, Hind III digestion and polyacrylamide gel electrophoresis.</p><p><b>RESULTS</b>The patients and normal control subjects were all homozygous for the normal G20210G allele, and there was no FII G20210A variant.</p><p><b>CONCLUSION</b>Factor II gene 3'-UT G20210A mutant allele is absent in the 99 Chinese Zhuang ethnic patients with ischemic stroke and myocardial infarction and is absent in 106 normal healthy Zhuang people. FII G20210A mutation may not be a major risk factor for thrombogenesis in ethnic Chinese.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Protrombina
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Análise Mutacional de DNA
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Sequência de Bases
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Etnicidade
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China
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Reação em Cadeia da Polimerase
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Predisposição Genética para Doença
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Regiões 3' não Traduzidas
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Trombose Intracraniana
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Frequência do Gene
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2005
Tipo de documento:
Article