Detection of Borna disease virus-p24 specific antibody in the sera of schizophrenic patients of China by means of Western-blot / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
; (6): 85-87, 2003.
Article
em Zh
| WPRIM
| ID: wpr-281847
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>To investigate whether Borna disease virus (BDV) infection is related to the schizophrenic patients from China.</p><p><b>METHODS</b>A reliable Western-blot method for detection of BDV-p24 antibody was established by adjusting the reaction conditions of BDV-p24 recombinant protein and specific antibodies. The sera of schizophrenic patients and normal controls from Heilongjiang Province were screened for specific BDV-p24 antibody by this method, and the BDV-p24 antibody positive sera were confirmed by the Western-blot method with sera-GST protein absorption.</p><p><b>RESULTS</b>Ten of 116 (8.6%) schizophrenic patients were found to be positive for BDV-p24 specific antibody, while no BDV-p24 specific antibody was found in sera of normal controls.</p><p><b>CONCLUSIONS</b>The results demonstrate that the Borna disease virus infection also exists in China, and the infection is possibly associated with schizophrenia in some way.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Esquizofrenia
/
Proteínas Virais
/
Virologia
/
Sangue
/
Vírus da Doença de Borna
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Western Blotting
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Alergia e Imunologia
/
Anticorpos Antivirais
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Experimental and Clinical Virology
Ano de publicação:
2003
Tipo de documento:
Article