Expression of IL-17A during Thymus Regeneration in the Rat / 체질인류학회지
Korean Journal of Physical Anthropology
; : 141-154, 2011.
Article
em Ko
| WPRIM
| ID: wpr-28209
Biblioteca responsável:
WPRO
ABSTRACT
IL-17A is a pro-inflammatroy cytokine secreted by activated T cells. The IL-17 family consist of IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17A and IL-17F are produced primarily in activated T cells. In contrast, IL-17B, IL-17C, IL-17D and IL-17E are expressed in a wide assortment of tissues. Their functions partially overlap those of IL-17A, although they have not been as thoroughly investigated. The receptor for IL-17A (IL-17R) is widely expressed in a variety of tissues. IL-17A and IL-17E mRNAs were expressed in only EL4 cells. IL-17C mRNA expression was observed in the thymic subcapsular/cortex epithelial cells (SNEC), cortex or cortical reticular cells (CREC), medullary epithelial cells (MEC), medullary interdigitating-like cells (MDC), thymocytes and EL4 cells. However, IL-17C mRNA was not expressed in RAW 264.7 cells. Immunohistochemical study also demonstrated not only the presence of IL-17A mainly in the thymic epithelial cells, but also the upregulated expression of IL-17A in the thymic epithelial cells of the regenerating thymus. Thus, the results of the present study suggest that IL-17A expressed in the thymocytes and thymic epithelial cells could play an important role in the development of new T cells to replace T cells damaged by cyclophosphamide treatment during thymus regeneration.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Regeneração
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Timo
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RNA Mensageiro
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Linfócitos T
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Interleucina-17
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Ciclofosfamida
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Células Epiteliais
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Timócitos
Limite:
Animals
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Humans
Idioma:
Ko
Revista:
Korean Journal of Physical Anthropology
Ano de publicação:
2011
Tipo de documento:
Article