CTLA-4 gene A/G polymorphism associated with diabetes mellitus in Han Chinese / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1248-1250, 2002.
Article
em En
| WPRIM
| ID: wpr-282133
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene A/G polymorphism with susceptibility to diabetes mellitus in Han Chinese.</p><p><b>METHODS</b>An A/G transition at position 49 of exon 1 was analyzed in 31 patients with type 1 diabetes, 31 patients with type 2 diabetes, and 36 controls were analyzed by polymerase chain reaction-restriction fragment length polymorphism analysis.</p><p><b>RESULTS</b>A highly significant increase in the frequency of the G allele was seen in patients with type 1 diabetes compared with controls (66.1 % vs. 34.7%, respectively; P < 0.0005; OR = 3.670) . This reflected an increase in the GG genotype in patients (48.4% vs. 22.2%, respectively; P =0.025; OR =3.281) and a significant decrease in the AA genotype (16.1 % vs. 52.8%, respectively; P = 0.002). The allele frequencies of A and G in patients with type 2 diabetes were not significantly different from controls(A/G, 50.0/50.0% vs. 65.3/34.7%; P = not significant) . The distribution of genotype, however, differed significantly. This difference reflected an increase in the AG genotype in patients (54.8% vs.25.0%, respectively; P=0.012; OR=3.643) and a decrease in the AA genotype (22.6% vs. 52.8%, respectively; P=0.011).</p><p><b>CONCLUSIONS</b>CTLA-4 49 AA is protective from diabetes mellitus, whereas, CTLA-4 49 G allele (both as homozygotes and as heterozygotes ) confers an increased risk of diabetes mellitus.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Polimorfismo Genético
/
Antígenos de Diferenciação
/
Antígenos CD
/
China
/
Imunoconjugados
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Diabetes Mellitus
/
Etnologia
/
Antígeno CTLA-4
/
Abatacepte
/
Genética
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2002
Tipo de documento:
Article