Expression of growth-associated protein 43 in the hippocampus of mesial temporal lobe epilepsy mouse model / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 589-594, 2013.
Article
em Zh
| WPRIM
| ID: wpr-285955
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the temporal and spatial distribution of growth-associated protein 43(GAP-43)and phosphorylated growth-associated protein 43(p-GAP-43)in the dentate gyrus of mesial temporal lobe epilepsy(MTLE)mouse model.</p><p><b>METHODS</b>MTLE mouse model was established by using the kainic acid(KA)induction. Immunohistochemistry and Western blotting were applied to detect the expressions of GAP-43 and p-GAP-43 in different stages of epileptogenesis.</p><p><b>RESULTS</b>Both in the epileptic and control mice, high GAP-43 expression level was detected in the dentate gyrus, hilus, and inner molecular layer of hippocampus. Decreased p-GAP-43 expression was detected 5 days, 2 weeks, and 5 weeks after KA-induced seizures.</p><p><b>CONCLUSION</b>The decreased p-GAP-43 expression in the duration of seizure may play an important role in the synaptic reorganization of the sclerotic hippocampus.</p>
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Base de dados:
WPRIM
Assunto principal:
Convulsões
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Giro Denteado
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Proteína GAP-43
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Modelos Animais de Doenças
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Epilepsia
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Epilepsia do Lobo Temporal
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Hipocampo
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Ácido Caínico
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Metabolismo
Limite:
Animals
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2013
Tipo de documento:
Article