Association between SNPs in DNMT1 and noise-induced hearing loss in Chinese Han population / 中华劳动卫生职业病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the association between single nucleotide polymorphisms (SNPs) in DNA methyltransferase 1 (DNMT1) (rs12984523, rs16999593, and rs2228612) and noise-induced hearing loss (NIHL) in Chinese Han population.</p><p><b>METHODS</b>This case-control study consisted of 188 cases (case group) and 300 controls (control group) in the same working position, who were matched for age and gender. The cases had a binaural average high-frequency hearing threshold not less than 40 dB, and the controls had a binaural average high-frequency hearing threshold less than 40 dB. The genotypes at the three SNPs were determined by TaqMan probe.</p><p><b>RESULTS</b>TT genotype at DNMT1 rs2228612 is a risk factor for NIHL (adjusted OR = 1.69, 95% CI 1.14-2.52).</p><p><b>CONCLUSION</b>The study of Chinese Han population suggested that DNMT1 rs2228612 is associated with susceptibility to NIHL.</p>