Study on the genetic association between the polymorphism of cytosolic phospholipase A2 family genes and schizophrenia / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 173-176, 2008.
Article
em Zh
| WPRIM
| ID: wpr-287846
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the genetic association between the polymorphism of cytosolic phospholipase A2 (cPLA2) family genes and schizophrenia in the North Han Chinese.</p><p><b>METHODS</b>Method of polymerase chain reaction-based ligase detection reaction (PCR-LDR) was applied to genotype 10 single nucleotide polymorphisms (SNPs) of cPLA2 family genes among 201 pedigrees consisting of fathers, mothers and affected offsprings with schizophrenia. Haplotype relative risk (HRR) test, transmission disequilibrium test (TDT), haplotype transmission analysis and multiple locus analysis were conducted to analyze the genotyping data.</p><p><b>RESULTS</b>The genotypic frequency of cPLA2 gene did not deviate from Hardy-Weinberg equilibrium in both case and control groups. HRR and TDT showed that the 10 SNPs were not associated with schizophrenia (P > 0.05). Analysis for haplotype transmission showed that no haplotype systems was associated with schizophrenia (P > 0.05). Results from COA and COG tests showed a disease association for the rs2162886-rs1668589, rs891014-rs1668589 and rs2307279-rs7542180 combinations (chi2 = 6.913, P = 0.032; chi2 = 8.393, P = 0.015; chi2 = 8.447, P = 0.038).</p><p><b>CONCLUSION</b>Many loci in the cPLA2 family genes were associated with schizophrenic.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Esquizofrenia
/
Haplótipos
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China
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Epidemiologia
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Povo Asiático
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Fosfolipases A2 Citosólicas
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Frequência do Gene
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Genética
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
Zh
Revista:
Chinese Journal of Epidemiology
Ano de publicação:
2008
Tipo de documento:
Article