Hypnotic effect of Chinese materia medica Cynanchum chinese in mice / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1774-1776, 2007.
Article
em Zh
| WPRIM
| ID: wpr-287897
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the central pharmacological effect of the water and chloroform-extract compounds from C. chinese in mice.</p><p><b>METHOD</b>The independent activity test and the hypnotic synergism test by sub-threshold hypnotic dosage of pentobarbital were employed to evaluate the central pharmacological effect of the extract-compounds, and the minimal neurotoxicity was evaluated by the rotorod test.</p><p><b>RESULT</b>the extract-compounds exhibited significant dose-related inhibition effect of the spontaneous motor activity in mice after intraperitoneal administration. And the two extract-compounds promoted the hypnotic effect by sub-threshold hypnotic dosage administration of pentobarbital, and produced ED50 value of 2.36 g kg (-1) and 0.75 g kg(-1), respectively. Also, both extract-compounds showed no neurotoxicity in the experiment.</p><p><b>CONCLUSION</b>The extract compounds from C. chinese showed inhibitional effect on CNS.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Pentobarbital
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Farmacologia
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Fisiologia
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Plantas Medicinais
/
Sono
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Medicamentos de Ervas Chinesas
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Água
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Distribuição Aleatória
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Sistema Nervoso Central
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Química
Limite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2007
Tipo de documento:
Article
País de publicação:
CHINA
/
CN
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REPUBLIC OF CHINA