Real world study of affect on liver function of overdose of salvianolate extract injection / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 3092-3098, 2013.
Article
em Zh
| WPRIM
| ID: wpr-291376
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To understand the affect on liver function of using salvianolate injection above the recommended dose.</p><p><b>METHOD</b>Nationwide, research of hospital information system (HIS) data from 18 general hospitals comprising 14 191 patients was carried out. Two groups of patients were studied and their blood tests monitored before and after injections. One group received the recommended dose of 200 mg, the other exceeded it. To take into account group differences the propensity score method and logstic regression was used alongside liver function.</p><p><b>RESULT</b>When salvianolate injection was administered above the recommended dose patients were more likely to have abnormal AST and ALT levels. However, the difference between the groups was not statistically significant.</p><p><b>CONCLUSION</b>According to our data the affect of exceeding the recommended dose of salvianolate injection on liver function is not significant. However, monitoring of liver function should be carried out in clinic.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Aspartato Aminotransferases
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Medicamentos de Ervas Chinesas
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Extratos Vegetais
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Estudos de Casos e Controles
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Sistemas de Informação Hospitalar
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Alanina Transaminase
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Relação Dose-Resposta a Droga
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Pontuação de Propensão
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Ensaios Clínicos Pragmáticos como Assunto
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Infusões Parenterais
Tipo de estudo:
Clinical_trials
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Observational_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Ano de publicação:
2013
Tipo de documento:
Article