Research progress of TSPY1 gene family / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 600-603, 2014.
Article
em Zh
| WPRIM
| ID: wpr-291721
Biblioteca responsável:
WPRO
ABSTRACT
TSPY1 (testis-specific protein, Y-linked 1) gene family, located in male-specific region of Y-chromosome (MSY), has the maximum number of copies organized as a long tandem repeat array in protein-coding gene families of human genome. TSPY1 is identified to be the most important candidate gene for gonadoblastoma, and its coding protein can promote the proliferation and differentiation of tumor cells. Recently, TSPY1 gene family is also proposed to play an important role in spermatogenesis. In this review, the structure characteristics of the gene family were illustrated, and the functional studies of TSPY1 in the process of tumorigenesis and spermatogenesis were discussed.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Espermatogênese
/
Neoplasias Testiculares
/
Gonadoblastoma
/
Dosagem de Genes
/
Proteínas de Ciclo Celular
/
Predisposição Genética para Doença
/
Cromossomos Humanos Y
/
Genética
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2014
Tipo de documento:
Article