The effect of basic fibroblast growth factor (bFGF) on neovascularization and prefabricated flap survival / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effect of basic fibroblast growth factor (bFGF) on neovascularization and prefabricated flap survival.</p><p><b>METHODS</b>Male New-Zealand rabbits weighting 2.0-2.5 kg were used in this study. The experimental model used a prefabricated neck flap, supplied by the transferred and implanted central vascular bundle of the ear. 9 micrograms bFGF and 0.2 ml of normal saline was instilled in the vascular pedicle of the experimental and the control group respectively. After 1, 2, 3 weeks of operation, the neovascularization was studied by confocal laser scanning microscope (CLSM) and flap survival was observed.</p><p><b>RESULTS</b>The neovascularization and survival of the prefabricated flap was different in the experimental and the control groups. The experimental group was better than the control group.</p><p><b>CONCLUSION</b>bFGF treatment improved sprouting of the implanted vessel and the prefabricated flap survival.</p>