Treatment of recurrent malignant gliomas by surgery combined with recombinant adenovirus-p53 injection / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 709-712, 2010.
Article
em Zh
| WPRIM
| ID: wpr-293520
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and toxicity of combination therapy with surgery and recombinant adenovirus-p53 injection of recurrent malignant gliomas.</p><p><b>METHODS</b>38 patients with recurrent malignant gliomas were included in this study. Among them, 18 patients of combined treatment group had Ommaya reservoirs placed into the tumor cavities after the resection of the tumors and received regular recombinant adenovirus-p53 injections after the operation. The other 20 patients received surgery alone.</p><p><b>RESULTS</b>The 6-month and 1-year survival rates after the combination therapy were 66.7% (14/18) and 44.4% (8/18), respectively. The median survival time was 9.7 months. Compared with the surgery-alone group, the combined treatment group achieved significant improvement (P < 0.05). The Karnofsky score was significantly improved at 6 months after the combination therapy compared with that before the treatment (P < 0.05).</p><p><b>CONCLUSION</b>The recombinant adenovirus-p53 injection is safe and effective in treatment of recurrent malignant gliomas. The combination therapy of surgery and recombinant adenovirus-p53 injection may improve the life quality and the prognosis in patients with recurrent malignant gliomas.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Cirurgia Geral
/
Terapêutica
/
Neoplasias Encefálicas
/
Proteínas Recombinantes
/
Terapia Genética
/
Adenoviridae
/
Taxa de Sobrevida
/
Seguimentos
/
Genes p53
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2010
Tipo de documento:
Article