Association between BIM gene and glucocorticoid resistance in children with acute lymphoblastic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 945-949, 2017.
Article
em Zh
| WPRIM
| ID: wpr-297180
Biblioteca responsável:
WPRO
ABSTRACT
Acute lymphoblastic leukemia (ALL) is the most common malignant hematological disease in childhood. Glucocorticoids are frequently used in the chemoradiotherapy regimen for ALL and can induce the apoptosis of ALL cells through several signaling pathways, but about 10% of ALL children have poor response to glucocorticoids. Studies have revealed that glucocorticoids induce the apoptosis of ALL cells by upregulating the expression of BIM gene, and BIM gene is associated with glucocorticoid resistance in childhood ALL. This article reviews the recent studies on glucocorticoid resistance in childhood ALL, especially the role of BIM and its expression products in this process.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
/
Resistência a Medicamentos
/
Apoptose
/
Usos Terapêuticos
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Tratamento Farmacológico
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Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Proteína 11 Semelhante a Bcl-2
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Genética
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Glucocorticoides
Limite:
Child
/
Humans
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2017
Tipo de documento:
Article