Establishment of a diagnostic model of serum protein fingerprint pattern for esophageal cancer screening in high incidence area and its clinical value / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 441-443, 2007.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-298580
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the alterations of serum proteomic pattern in esophageal squamous cell carcinoma (ESCC) by SELDI-TOF-MS, to establish a diagnostic model of ESCC screening in high incidence area and investigate its clinical value.</p><p><b>METHODS</b>SELDI-TOF-MS and CM10 proteinChip were used to detect the serum proteomic patterns of 36 cases of ESCC and 38 healthy control subjects in high incidence area. The data were analyzed and a diagnostic model was established by using support vector machine (SVM). The diagnostic model was evaluated by leave-one-out cross validation.</p><p><b>RESULTS</b>At the molecular weight range of 2000 to 20,000, 31 protein peaks were significantly different between ESCC and controls (P < 0.01). A diagnostic model consisting of 4 protein peaks could do the best in diagnosis of ESCC and controls. The accuracy was 85.1%, sensitivity was 86.1%, specificity was 84.2%, and positive value was 83.8%.</p><p><b>CONCLUSION</b>The diagnostic model formed by 4 protein peaks, established in this study, can well distinguish ESCC from healthy subjects. It provides a new approach for ESCC screening in high incidence area.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
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Doenças do Sistema Digestório
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Neoplasia Esofágica
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sangue
/
Mapeamento de Peptídeos
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Neoplasias Esofágicas
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Proteínas Sanguíneas
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Carcinoma de Células Escamosas
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Química
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China
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Programas de Rastreamento
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Epidemiologia
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Incidência
Tipo de estudo:
Estudo diagnóstico
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Estudo de incidência
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Estudo prognóstico
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Estudo de rastreamento
Limite:
Adulto
/
Idoso
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Chinese Journal of Oncology
Ano de publicação:
2007
Tipo de documento:
Artigo